TRIP6 promotes inflammatory damage via the activation of TRAF6 signaling in a murine model of DSS-induced colitis.

Yun YangXiu-Ming LiJing-Ru WangYan LiWen-Long YeYi WangYu-Xuan LiuZhi-Yong DengWen-Juan GanHua Wu

Published in: Journal of inflammation (London, England) (2022)

These in vivo data demonstrate that TRIP6 serves as a positive regulator of DSS-induced colitis through interactions with TRAF6 resulting in the activation of inflammatory TRAF6 signaling, highlighting its therapeutic promise as a protein that theoretically can be targeted to prevent or treat colitis.

Keyphrases

oxidative stress
big data
electronic health record
cancer therapy
machine learning
drug delivery
protein protein
artificial intelligence
ulcerative colitis