TRIP6 promotes inflammatory damage via the activation of TRAF6 signaling in a murine model of DSS-induced colitis.
Yun YangXiu-Ming LiJing-Ru WangYan LiWen-Long YeYi WangYu-Xuan LiuZhi-Yong DengWen-Juan GanHua WuPublished in: Journal of inflammation (London, England) (2022)
These in vivo data demonstrate that TRIP6 serves as a positive regulator of DSS-induced colitis through interactions with TRAF6 resulting in the activation of inflammatory TRAF6 signaling, highlighting its therapeutic promise as a protein that theoretically can be targeted to prevent or treat colitis.