Histamine H4 receptor regulates IL-6 and INF-γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis.
Hua PengJian WangXiao Yan YeJie ChengCheng Zhi HuangLi Yue LiTian Ying LiChun Wei LiPublished in: Clinical and translational allergy (2019)
Histamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monocytes remain unclear. In the current study, the responses of H4R in peripheral monocytes from patients with allergic rhinitis (AR) were investigated. The results confirmed that H4R has the functional effects of mediating cytokine production (i.e., down-regulating IFN-γ and up-regulating IL-6) in cells from a monocyte cell line following challenge with histamine. We demonstrated that when monocytes from AR patients were stimulated with allergen extracts of house dust mite (HDM), IFN-γ secretion was dependent on H4R activity, but IL-6 secretion was based on H1R activity. Furthermore, a combination of H1R and H4R antagonists was more effective at blocking the inflammatory response in monocytes than treatment with either type of antagonist alone.
Keyphrases
- allergic rhinitis
- dendritic cells
- peripheral blood
- inflammatory response
- immune response
- end stage renal disease
- ejection fraction
- oxidative stress
- prognostic factors
- binding protein
- patient reported outcomes
- toll like receptor
- lps induced
- health risk
- drinking water
- human health
- climate change
- health risk assessment