Population Pharmacokinetics of Hydroxychloroquine in COVID-19 Patients: Implications for Dose Optimization.

Pauline ThémansLeila BelkhirNicolas DaubyJean-Cyr YombiJulien De GreefKevin-Alexandre DelongieMartin VandeputteRakan NasreddineXavier WitteboleFrancoise WuillaumeCécile LescrainierVeerle VerlindenSophie KiridisJean-Michel DognéJamila HamdaniPierre WallemacqFlora T Musuamba

Published in: European journal of drug metabolism and pharmacokinetics (2020)

The developed models provide useful insight for the dosing optimization of hydroxychloroquine in COVID-19 patients. The present results should be used in conjunction with exposure-efficacy and exposure-safety data to inform optimal dosing of hydroxychloroquine in COVID-19.

Keyphrases

sars cov
coronavirus disease
respiratory syndrome coronavirus
big data
machine learning