Fetal cardiac hemodynamics and neonatal cerebral hemodynamics and oxygen metabolism in transposition of the great arteries.

Fetal cardiac and neonatal cerebral hemodynamic/metabolic alterations were observed in both TGA groups compared to controls. Compared to TGA&IVS, fetuses with TGA&VSD had lower RVO and CVO in late gestations. A higher level of preoperative hypoxemia was observed in TGA&VSD. Post-surgical cerebral adaptive mechanisms are likely different between TGA groups. Patients with TGA&VSD have a specific physiology that needs to be further studied to improve neonatal care and neurodevelopmental outcome. This article is protected by copyright. All rights reserved.