Embryonic stem cells overexpressing high molecular weight FGF2 isoform enhance recovery of pre-ganglionic spinal root lesion in combination with fibrin biopolymer mediated root repair.

B H M LimaL P CartarozziS KyrylenkoR S FerreiraB BarravieraAlexandre Leite Rodrigues de Oliveira

Published in: Stem cell research & therapy (2024)

Transgenic hESCs were an effective delivery platform for neurotrophic factors, rescuing axotomized motoneurons and modulating glial response after proximal spinal cord root injury, while the 31 kD isoform of FGF2 showed superior regenerative properties over other isoforms in addition to the significant functional recovery.

Keyphrases

spinal cord
embryonic stem cells
neuropathic pain
stem cells
mesenchymal stem cells
spinal cord injury
signaling pathway
cell therapy
high throughput
bone marrow