Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung.
Timo H LüdtkeIrina WojahnMarc-Jens KleppaJasper SchierstaedtVincent M ChristoffelsPatrick KünzlerAndreas KispertPublished in: Respiratory research (2021)
Our data suggest that TBX2 interacts with homeobox and HMG-box transcription factors as well as with the NuRD chromatin remodeling complex to repress transcription of anti-proliferative genes in the pulmonary mesenchyme.
Keyphrases
- transcription factor
- dna binding
- genome wide
- genome wide identification
- copy number
- pulmonary hypertension
- electronic health record
- dna methylation
- big data
- binding protein
- single cell
- hiv testing
- bioinformatics analysis
- label free
- dna damage
- men who have sex with men
- machine learning
- hepatitis c virus
- genome wide analysis
- deep learning