Photothermal Fenton Nanocatalysts for Synergetic Cancer Therapy in the Second Near-Infrared Window.
Haitao SunYaying ZhangSiyu ChenRuizhi WangQian ChenJingchao LiYu LuoXiaolin WangHang-Rong ChenPublished in: ACS applied materials & interfaces (2020)
Chemodynamic therapy (CDT) that utilizes endogenous hydrogen peroxide (H2O2) to produce reactive oxygen species (ROS) to kill cancer cells has shown a promising strategy for malignant tumor treatment. Nevertheless, limited H2O2 levels in the tumor microenvironment often compromise the therapeutic benefits of CDT, leading to cancer recurrence and metastasis. Herein, a second near-infrared (NIR-II) photothermal Fenton nanocatalyst (PFN) was developed for activatable magnetic resonance imaging (MRI)-guided synergetic photothermal therapy (PTT) and CDT of pancreatic carcinoma. Such a PFN consists of manganese dioxide (MnO2), copper sulfide (CuS), and human serum albumin (HSA), which serve as the activatable imaging contrast agent, the NIR-II photothermal agent and Fenton catalyst, and the stabilizer, respectively. The acidic tumor microenvironment increased the relaxivity of PFN by 2.1-fold, allowing for improved imaging performance and monitoring of nanoparticle accumulation in tumors. Under NIR-II laser irradiation at 1064 nm, PFN generates local heat, which not only permits PTT but also enhances the nanocatalyst-mediated Fenton-like reaction. As such, PFN exerts a synergetic action to completely ablate xenografted tumor models in living animals, while the sole CDT fails to do so. This study thus provides an NIR-II photothermal nanocatalyst for potential treatment of deep-seated tumors.
Keyphrases
- photodynamic therapy
- hydrogen peroxide
- fluorescence imaging
- cancer therapy
- drug release
- magnetic resonance imaging
- drug delivery
- fluorescent probe
- reactive oxygen species
- nitric oxide
- wastewater treatment
- contrast enhanced
- human serum albumin
- computed tomography
- magnetic resonance
- cell death
- replacement therapy
- dna damage
- gold nanoparticles
- heat stress
- oxidative stress
- bone marrow
- radiation induced
- high speed
- stem cells
- squamous cell
- highly efficient
- visible light