Chemomodulatory Effect of the Marine-Derived Metabolite "Terrein" on the Anticancer Properties of Gemcitabine in Colorectal Cancer Cells.

Reham Khaled AbuhijjlehDalia Yousef Al SaeedyNaglaa S AshmawyAhmed E GoudaSameh S Elhady Ahmed Mohamed Al-Abd

Published in: Marine drugs (2023)

Terrein influenced GCB's anti-colorectal cancer properties which are reflected in different aspects such as cytotoxicity, cell cycle progression, apoptosis, autophagy, and intra-tumoral metabolism under normoxic and hypoxic conditions.

Keyphrases

cell cycle
endoplasmic reticulum stress
cell death
cell proliferation
oxidative stress
cell cycle arrest
signaling pathway
locally advanced
radiation therapy
pi k akt