The role of cellular senescence in profibrillatory atrial remodelling associated with cardiac pathology.

Mozhdeh MehdizadehPatrice NaudIssam H Abu-TahaRoddy HiramFeng XiongJiening XiaoArnela SaljicMarkus KamlerNhung Vuong-RobillardÉric Thorin Gerardo Ferbeyre Jean Claude TardifMartin G SiroisJean Francois TanguayDobromir Dobrev Stanley Nattel

Published in: Cardiovascular research (2024)

Our results point to a potentially significant role of cellular senescence in AF pathophysiology. Modulating cell senescence might provide a basis for novel therapeutic approaches to AF.

Keyphrases

atrial fibrillation
dna damage
endothelial cells
stress induced
single cell
left ventricular
cell therapy
heart failure
catheter ablation
oxidative stress
mesenchymal stem cells
bone marrow