Integrated proteomics spotlight the proteasome as a therapeutic vulnerability in embryonal tumors with multilayered rosettes.
Matthias DottermuschAli BiabaniTasja LempertzYannis SchumannJelena NavolicShweta GodboleDenise ObrechtStephan FrankMario M DorostkarHannah VoßHartmut SchlüterStefan RutkowskiUlrich SchüllerJulia E NeumannPublished in: Neuro-oncology (2024)
In summary, histomorphology stipulates the proteome signatures of ETMR, and proteasome regulatory proteins are pervasively abundant in these tumors. As validated in vitro, proteasome inhibition poses a promising therapeutic option in ETMR.