Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis.

Amit KumarEvan ElkoSierra R BrunoZoe F MarkNicolas ChamberlainBethany Korwin MihavicsRavishankar ChandrasekaranJoseph WalzerMona RubanClarissa GoldYing Wai LamSudhir GhandikotaAnil G JeggaJose L GomezYvonne Mw Janssen-HeiningerVikas Anathy

Published in: Thorax (2021)

Our study reveals a new relationship with distally localised club cells, PDIA3 and SPP1 in lung fibrosis and inhibition of PDIA3 or SPP1 attenuates lung fibrosis.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
signaling pathway