Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis.
Amit KumarEvan ElkoSierra R BrunoZoe F MarkNicolas ChamberlainBethany Korwin MihavicsRavishankar ChandrasekaranJoseph WalzerMona RubanClarissa GoldYing Wai LamSudhir GhandikotaAnil G JeggaJose L GomezYvonne Mw Janssen-HeiningerVikas AnathyPublished in: Thorax (2021)
Our study reveals a new relationship with distally localised club cells, PDIA3 and SPP1 in lung fibrosis and inhibition of PDIA3 or SPP1 attenuates lung fibrosis.