Login / Signup

Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis.

Amit KumarEvan ElkoSierra R BrunoZoe F MarkNicolas ChamberlainBethany Korwin MihavicsRavishankar ChandrasekaranJoseph WalzerMona RubanClarissa GoldYing Wai LamSudhir GhandikotaAnil G JeggaJose L GomezYvonne Mw Janssen-HeiningerVikas Anathy
Published in: Thorax (2021)
Our study reveals a new relationship with distally localised club cells, PDIA3 and SPP1 in lung fibrosis and inhibition of PDIA3 or SPP1 attenuates lung fibrosis.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • cell death
  • signaling pathway