Nasopharyngeal Large Cell Neuroendocrine Carcinoma Synchronized With Nasopharyngeal Squamous Cell Carcinoma: A Case Report and Review of Literature.
Yu-Wen LinChing-Heng TingTung-Ying ChenYi-Shing LeuPublished in: Ear, nose, & throat journal (2022)
Neuroendocrine carcinomas (NECs) are poorly differentiated neuroendocrine tumors of the upper respiratory tract. We present an extremely rare case of nasopharyngeal large cell neuroendocrine carcinoma (LCNEC) synchronized with nasopharyngeal squamous cell carcinoma (SCC). Both SCC and LCNEC are associated with Epstein-Barr virus (EBV) infection, supported by the positive result of Epstein-Barr encoding region in-situ hybridization. Strong correlation is found between EBV infection and nasopharyngeal malignancies. Furthermore, the EBV status might be a crucial prognostic factor in nasopharyngeal LCNEC. EBV-positive LCNEC is effective to chemoradiotherapy, and may have preferable outcome than EBV-negative LCNEC arising in the nasopharynx or other sites. The recognition of the EBV status is important for patients to receive appropriate treatment.
Keyphrases
- epstein barr virus
- diffuse large b cell lymphoma
- squamous cell carcinoma
- prognostic factors
- rare case
- respiratory tract
- single cell
- neuroendocrine tumors
- end stage renal disease
- locally advanced
- newly diagnosed
- cell therapy
- chronic kidney disease
- lymph node metastasis
- rectal cancer
- stem cells
- patient reported outcomes
- bone marrow
- high grade