In this work, a feasible method was proposed to prepare MoS 2 -based plasmonic hybrid systems with high photoluminescence (PL) emission enhancement. The enhancement effect of plasmonic hybrids on the PL emission of MoS 2 has been systematically studied on MoS 2 /Ag spherical nanoparticle (SP) hybrid systems with different architectures by changing the stacking position of Ag SPs. It is demonstrated that the sandwich-like hybrid composed of monolayer MoS 2 and dielectric Al 2 O 3 layer between two layers of Ag SPs has the highest PL enhancement. Remarkably, after adding an Al 2 O 3 layer under MoS 2 , the PL intensity enhancement up to 209 times was achieved in the sandwich-like hybrid system. Compared with the hybrid with single-layer SPs, the sandwich-like hybrid system with double-layer Ag SPs exhibited an obvious blue shift as a result of the selective enhancement of the A 0 exciton in MoS 2 . These results demonstrate that MoS 2 /Ag SP hybrid nanosystems have significant implications for sensing and photoelectronic devices.