Cytomegalovirus (CMV) management in allogeneic hematopoietic cell transplantation: Pre-transplant predictors of survival, reactivation, and spontaneous clearance.
Julian LindsayJad OthmanIan KerridgeKeith FayWilliam StevensonChris ArthurSharon C-A ChenDavid C M KongMirta Maravilla RosasCatherine LiuMonica A SlavinMatthew GreenwoodPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2021)
Overall, this study indicates that D-/R+ URD recipients are at high-risk for cs-CMVi- and CMV-related mortality, and are potential candidates for targeted CMV prophylaxis. Spontaneous clearance of CMV beyond a viral load of 250 IU/mL is uncommon, suggesting that this could be used as an appropriate threshold to initiate pre-emptive therapy.