PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort.
Aeron M SmallJennifer E HuffmanDerek KlarinJulie A LynchThemistocles L AssimesScott DuVallYan V SunLabiba SherePradeep NatarajanMichael GazianoDaniel J RaderPeter W F WilsonPhilip S TsaoKyong-Mi ChangKelly ChoChristopher J O'DonnellJuan P CasasScott M Damrauernull nullPublished in: PloS one (2020)
Genetically reduced PCSK9 function results in a reduction in risk of several important extra-coronary atherosclerotic phenotypes in addition to known effects on CAD and IS, including PAD and AAA. We also highlight a novel reduction in risk of dementia, supporting a well-recognized vascular component to cognitive impairment and an opportunity for therapeutic repositioning.