On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.

Sanghun LeeJulian HeckerGeorg HahnKristina Mullinnull nullSharon M LutzRudolph E TanziChristoph LangeDmitry Prokopenko

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

We observed substantial heterogeneity for the APOE-harboring 19q13.32 region with TOMM40/APOE/APOC1 genes. The largest risk effect was seen among African Americans, while Asians showed a surprisingly small risk effect.

Keyphrases

cognitive decline
genome wide
single cell
high fat diet
gene expression
metabolic syndrome
adipose tissue
insulin resistance
breast cancer risk