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Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series.

Nicolás AnselminoEstefanía LabancaPeter D A ShepherdJiabin DongJun YangXiaofei SongSubhiksha NandakumarRitika KundraCindy J LeeNikolaus SchultzJianhua ZhangJohn C AraujoAna M AparicioSumit K SubudhiPaul Gettys CornLouis L PistersJohn F WardJohn W DavisElba S VazquezGeraldine GueronChristopher L LogothetisP Andrew FutrealPatricia TroncosoJuliet ChenNora M Navone
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
We addressed the gap in clinically relevant prostate cancer models through comprehensive molecular characterization of MDA PCa PDXs, providing a discovery platform that integrates with patient data and benchmarked to therapeutically relevant consensus clinical groupings. This unique resource supports robust hypothesis generation and testing from basic, translational, and clinical perspectives.
Keyphrases
  • prostate cancer
  • radical prostatectomy
  • breast cancer cells
  • high throughput
  • small molecule
  • case report
  • molecular dynamics
  • big data
  • cell proliferation
  • clinical practice
  • deep learning