Downregulated miR-27b promotes keratinocyte proliferation by targeting PLK2 in oral lichen planus.

Junjun Chen Guan-Huan DuYuzhou ChangYufeng WangLinjun ShiJun MiGuoyao Tang

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)

There were aberrant expressions of miR-27b and PLK2 in OLP tissues. Decreased miR-27b may have induced cell proliferation by increasing the levels of PLK2 in HOKs, which provides a new perspective into the potential mechanisms underlying OLP development.

Keyphrases

cell proliferation
high glucose
gene expression
diabetic rats
signaling pathway
cell cycle
drug induced
oxidative stress
risk assessment