RNF213 gene mutation in circulating tumor DNA detected by targeted next-generation sequencing in the assisted discrimination of early-stage lung cancer from pulmonary nodules.
Ning JiangJie ZhouWenhao ZhangPeichao LiYu LiuHubo ShiChengke ZhangYunshan WangChengjun ZhouChuanliang PengWeiquan ZhangYingtao HaoQifeng SunYuliang LiXiaogang ZhaoPublished in: Thoracic cancer (2020)
Detection mutation of the RNF213 gene in peripheral blood may be a high specificity method for the assisted early diagnosis of lung cancer in pulmonary nodules.
Keyphrases
- circulating tumor
- peripheral blood
- early stage
- pulmonary hypertension
- cell free
- circulating tumor cells
- dna damage response
- copy number
- cancer therapy
- loop mediated isothermal amplification
- real time pcr
- label free
- gene expression
- genome wide identification
- squamous cell carcinoma
- radiation therapy
- oxidative stress
- drug delivery
- lymph node