TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.

Hong-Lei MaSui-Dan ChenKenneth I ZhengYue YuXin-Xin WangLiang-Jie TangGang LiRafael S RiosOu-Yang HuangXiao-Yong ZhengRen-Ai XuGiovanni TargherChristopher D ByrneXiao-Dong WangYong-Ping ChenMing-Hua Zheng

Published in: Journal of gastroenterology and hepatology (2021)

The TA allele of rs2070673 is strongly associated with lobular inflammation and NASH, and this effect appears to be largely mediated by serum IP-10 levels.

Keyphrases

oxidative stress
copy number
genome wide
gene expression
ultrasound guided
dna methylation
fine needle aspiration
liver fibrosis
transcription factor