Tandem chimeric antigen receptor (CAR) T cells targeting EGFRvIII and IL-13Rα2 are effective against heterogeneous glioblastoma.

Andrea SchmidtsAmbike A SrivastavaRishab RamapriyanStefanie R BaileyAmanda A BouffardDaniel P CahillBob S CarterWilliam T CurryGavin P DunnMatthew J FrigaultElizabeth R GerstnerJack Y GhannamMichael C KannRebecca C LarsonMark B LeickBrian V NahedLeland G RichardsonIrene ScarfòJing SunHiroaki WakimotoMarcela V MausBryan D Choi

Published in: Neuro-oncology advances (2022)

We demonstrate that TanCART is effective against heterogeneous tumors in the brain. These data lend further credence to the development of multi-specific CAR T cells in the treatment of GBM and other cancers.

Keyphrases

induced apoptosis
cell cycle arrest
white matter
big data
cancer therapy
endoplasmic reticulum stress
signaling pathway
oxidative stress
combination therapy
young adults
cell proliferation
replacement therapy
deep learning
data analysis