Methemoglobin in critically ill septic patients.
Atthaphong PhongphithakchaiAkinori MaedaYukiko HikasaSofia SpanoNuttapol PattaminAnis ChabaGlenn EastwoodHelen YoungLeah PeckRinaldo BellomoPublished in: Biomarkers in medicine (2024)
Aim: Higher nitric oxide (NO) levels correlate with adverse sepsis outcomes but are challenging to measure. Methemoglobin (MetHb), a measurable product of NO, has not been utilized for risk stratification. Methodology: All patients with sepsis admitted to the intensive care unit (ICU) that had at least one MetHb measurement within 24 h of ICU admission were retrospectively analyzed. We assessed the epidemiology and associations of MetHb with hospital mortality. Results: Among 7724 patients, 1046 qualified. Those with MetHb ≥1.6% showed significantly higher mortality and fewer days alive outside the hospital by day 28. MetHb levels ≥1.6% independently predicted increased 28-day mortality. Conclusion: Our findings suggest MetHb, easily obtainable from arterial blood gases, can significantly enhance sepsis risk stratification.
Keyphrases
- intensive care unit
- acute kidney injury
- nitric oxide
- cardiovascular events
- septic shock
- risk factors
- end stage renal disease
- healthcare
- ejection fraction
- emergency department
- newly diagnosed
- mechanical ventilation
- adverse drug
- chronic kidney disease
- prognostic factors
- type diabetes
- acute care
- coronary artery disease
- adipose tissue
- hydrogen peroxide
- patient reported
- drug induced