The mitochondrial calcium uniporter inhibitor Ru265 increases neuronal excitability and reduces neurotransmission via off-target effects.

Peng XuSarpras SwainRobyn J NovorolskyEsperanza GarciaZhouyang HuangTerrance P SnutchJustin J WilsonGeorge S RobertsonRobert B Renden

Published in: British journal of pharmacology (2024)

Our findings provide a mechanistic explanation for the pro-convulsant effects of Ru265 and suggest counter screening assays based on the measurement of P/Q and KCNQ channel currents to identify safe MCU inhibitors.

Keyphrases

oxidative stress
energy transfer
high throughput
transcranial direct current stimulation
brain injury
single cell