On-Demand Therapy with Proton Pump Inhibitors for Maintenance Treatment of Nonerosive Reflux Disease or Mild Erosive Esophagitis: A Systematic Review and Meta-Analysis.
Zubair KhanYaseen AlastalMuhammad Ali KhanMohammed Saud KhanBasmah KhalilShreesh ShresthaFaisal KamalAli NawrasColin W HowdenPublished in: Gastroenterology research and practice (2018)
On-demand PPI treatment is effective for many patients with NERD or mild EE. Although not FDA-approved, it may be adequate for those patients whose symptoms are controlled to their satisfaction.