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Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy.

Qiang ChengYuyan LiWei HuangKe LiMinhuan LanBenhua WangJianxiu WangXiangzhi Song
Published in: Chemical communications (Cambridge, England) (2023)
In this work, we presented a copper coordination-based conjugated polymer nanoparticle (PPE-Cu NPs) for synergistic PDT/CDT. Upon irradiation, PPE-Cu NPs exhibited good singlet oxygen generation capability ( Φ Δ = 0.33). Meanwhile, PPE-Cu NPs were able to generate ˙OH in the presence of GSH and H 2 O 2 . Cellular experiments demonstrated that PPE-Cu NPs can serve as effective agents for synergistic PDT/CDT therapy.
Keyphrases
  • oxide nanoparticles
  • photodynamic therapy
  • cancer therapy
  • aqueous solution
  • metal organic framework
  • mesenchymal stem cells
  • quantum dots
  • fluorescent probe
  • iron oxide