Patients with obesity have more inflamed joints and higher CRP levels during the disease course in ACPA-positive RA but not in ACPA-negative RA.
Nikolet K den HollanderAnna M P BoerenAnnette H M van der Helm van MilHanna W van SteenbergenPublished in: Arthritis research & therapy (2024)
The association of obesity with a worse DAS course is mainly present in ACPA-positive RA; especially SJC and CRP levels remain higher in ACPA-positive RA patients with obesity but not ACPA-negative RA patients. This is the first demonstration that obesity influences the disease course of ACPA-positive and ACPA-negative RA differently.
Keyphrases
- rheumatoid arthritis
- disease activity
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- ankylosing spondylitis
- systemic lupus erythematosus
- end stage renal disease
- interstitial lung disease
- ejection fraction
- chronic kidney disease
- adipose tissue
- prognostic factors
- skeletal muscle
- systemic sclerosis
- idiopathic pulmonary fibrosis