Adenosine production by brain cells.
Edwin K JacksonShawn E KotermanskiElizabeth V MenshikovaRaghvendra K DubeyTravis C JacksonPatrick M KochanekPublished in: Journal of neurochemistry (2017)
Under these particular experimental conditions, cultured neurons are the main contributors to adenosine production/release in response to OGD and glutamate, whereas cultured microglia are the main contributors upon oxidative stress. Developing therapeutics that recruit astrocytes to produce/release adenosine could have beneficial effects in TBI.
Keyphrases