Adenosine production by brain cells.
Edwin K JacksonShawn E KotermanskiElizabeth V MenshikovaRaghvendra K DubeyTravis C JacksonPatrick M KochanekPublished in: Journal of neurochemistry (2017)
Under these particular experimental conditions, cultured neurons are the main contributors to adenosine production/release in response to OGD and glutamate, whereas cultured microglia are the main contributors upon oxidative stress. Developing therapeutics that recruit astrocytes to produce/release adenosine could have beneficial effects in TBI.
Keyphrases
- induced apoptosis
- oxidative stress
- protein kinase
- endothelial cells
- traumatic brain injury
- cell cycle arrest
- spinal cord
- inflammatory response
- white matter
- endoplasmic reticulum stress
- small molecule
- dna damage
- signaling pathway
- ischemia reperfusion injury
- severe traumatic brain injury
- cell death
- diabetic rats
- cell proliferation
- pi k akt
- subarachnoid hemorrhage