AMP-activated protein kinase inhibition in fibro-adipogenic progenitors impairs muscle regeneration and increases fibrosis.

Xiangdong LiuLiang ZhaoYao GaoYanting ChenQiyu TianJun Seok SonSong Ah ChaeJeanene Marie de AvilaMei-Jun ZhuMin Du

Published in: Journal of cachexia, sarcopenia and muscle (2022)

These data suggest that AMPK is a key mediator of FAPs apoptosis, and its inhibition due to obesity results in fibrosis of regenerated muscle.

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