Ischemic Stroke with Comorbid Cancer Has Specific miRNA-mRNA Networks in Blood That Vary by Ischemic Stroke Mechanism.

Bodie Knepp Babak Benjamin NaviFernando RodriguezLisa M DeAngelisMitchell S V ElkindCostantino IadecolaCarla P ShermanScott T TagawaAshish SaxenaAllyson J OceanHeather HullGlen JicklingFrank R SharpBradley P AnderBoryana Stamova

Published in: Annals of neurology (2024)

We discovered unique mRNA and miRNA transcriptome architecture in CS and SO, and in CS with different IS etiologies. Cardioembolic and noncardioembolic etiologies in CS showed unique coexpression networks and potential master regulators. These may help distinguish CS from SO and identify IS etiology in cryptogenic CS patients. ANN NEUROL 2024.

Keyphrases

end stage renal disease
atrial fibrillation
newly diagnosed
chronic kidney disease
papillary thyroid
single cell
binding protein
rna seq
genome wide
transcription factor
squamous cell carcinoma
patient reported outcomes
dna methylation
network analysis
climate change
squamous cell
human health