What about chronotropic incompetence in heart failure with mildly reduced ejection fraction? Clinical and prognostic implications from the MECKI score data-set.
Damiano MagrìGiovanna GalloMassimo PiepoliElisabetta SalvioniMassimo MapelliCarlo VignatiEmiliano FioriMelwyn Luis MuthukkattilUgo CorràMarco Me TraStefania PaolilloPasquale Perrone FilardiAntonello MaruottiPierfrancesco Alaimo Di LoroMichele SenniRocco LagioiaDomenico ScrutinioMichele EmdinClaudio PassinoGianfranco ParatiGianfranco SinagraMichele CorrealeRoberto BadagliaccaSusanna SciomerAndrea Di LenardaPiergiuseppe AgostoniPublished in: European journal of preventive cardiology (2023)
The study suggests an association between blunted exercise-HR response, functional capacity, and CV death risk among patients with HFmrEF. Whether the CI presence might be adopted in daily HFmrEF management needs to be addressed in larger prospective studies.