Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis.

David MoulinMarie MillardMahdia TaïebChloé MichaudelAnne AucouturierAntoine LefèvreLuis G Bermúdez-HumaránPhilippe LangellaYoussouf SeremeKristell WanherdrickPreeti GautamXavier Mariette Philippe Dieude Jacques-Eric GottenbergJean-Yves JouzeauDavid SkurnikPatrick EmondDenis MullemanJérémie SellamHarry Sokol

Published in: Annals of the rheumatic diseases (2023)

Altogether, our preclinical and clinical data indicate that alterations in the Trp metabolism play an active role in the pathogenesis of RA and could be considered as a new therapeutic avenue.

Keyphrases

rheumatoid arthritis
disease activity
interstitial lung disease
cell therapy
machine learning
bone marrow
deep learning