The function of tcf3 in medaka embryos: efficient knockdown with pePNAs.
Gerlinde DoenzSebastian DornNarges AghaallaeiBaubak BajoghliElisabeth RiegelMichaela AignerHolger BockBirgit WernerThomas LindhorstThomas CzernyPublished in: BMC biotechnology (2018)
Our results show that side chain modified PNAs come close to the knockdown efficiency of morpholino oligonucleotides in vivo. A single medaka tcf3 gene combines the function of the two zebrafish paralogs hdl and tcf3b. In combination with Groucho/Tle corepressor proteins Tcf3 acts in anterior development and is critical for eye formation.
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