Interactions Between Genetic Risk and Diet Influencing Risk of Incident Female Gout: Discovery and Replication Analysis of Four Prospective Cohorts.
Kehuan LinNatalie McCormickChio YokoseAmit D JoshiNa LuGary C CurhanTony Raymond MerrimanKenneth G SaagPaul M RidkerJulie E BuringDaniel I ChasmanFrank B HuHyon K ChoiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
The deleterious effect of genetic predisposition on risk of incident female gout was more pronounced among women with unhealthy diets, with nearly half the excess risk attributable to this gene-diet interaction. These data elucidate the important synergy of genetics and diet for female gout development.