The Effect of Physical Exercise Pretreatment on Spatial Memory and Learning and Function of Mitochondria in the Brain in Type 2 Diabetic Rats.

Homayoon Behmadi Fatemeh Samiei Marzieh NoruziZahra Halvaei KhankahdaniShokoufeh Hassani Maryam Mehdizadeh Jalal PourahmadGhorban TaghizadehMohammad Sharifzadeh

Published in: Iranian journal of pharmaceutical research : IJPR (2023)

This study reveals that physical exercise could prevent diabetes-induced spatial memory impairment. Moreover, it could ameliorate brain mitochondrial dysfunction as one of the possible underlying mechanisms of spatial memory impairment in T2DM.

Keyphrases

working memory
resting state
white matter
type diabetes
glycemic control
high glucose
functional connectivity
multiple sclerosis
oxidative stress
metabolic syndrome
drug induced
skeletal muscle
endothelial cells
blood brain barrier
brain injury