Synthesis and Encapsulation of Ajuga parviflora Extract with Zeolitic Imidazolate Framework-8 and Their Therapeutic Action against G + and G - Drug-Resistant Bacteria.
Ab Majeed AhangerSuresh KumarAtul AryaAmrita SuryavanshiDolly Kainnull VandanaPublished in: ACS omega (2022)
Infectious diseases caused by bacteria have become a public health issue. Antibiotic therapy for infectious disorders, as well as antibiotic overuse, has resulted in antibiotic-resistant bacterial strains. Zeolitic imidazolate framework-8 (ZIF-8) possesses a wide surface area, high porosity, variable functionality, and potential drug carriers. We have established a clear method for making a nanoscale APE@ZIF-8 nanocomposite agent with outstanding antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and cephalosporin-carbapenem-resistant Escherichia coli (CCREC). We present a unique approach for encapsulating molecules of Ajuga parviflora extract (APE) with ZIF-8. APE@ZIF-8 has a positive charge. By electrostatic contact with the negatively charged bacterial surface of S. aureus and E. coli , APE@ZIF-8 NPs produce reactive oxygen species (ROS) that damage bacterial cell organelles. As a result, the APE@ZIF-8 nanocomposite offers limitless application potential in the treatment of infectious disorders caused by drug-resistant gram-positive and gram-negative bacteria.
Keyphrases
- drug resistant
- methicillin resistant staphylococcus aureus
- multidrug resistant
- escherichia coli
- acinetobacter baumannii
- public health
- gram negative
- reactive oxygen species
- infectious diseases
- staphylococcus aureus
- oxidative stress
- reduced graphene oxide
- cell death
- klebsiella pneumoniae
- quantum dots
- human health
- cystic fibrosis
- high resolution
- bone marrow
- pseudomonas aeruginosa
- atomic force microscopy
- solid phase extraction
- highly efficient