[Nimodipine in treatment of bipolar disorder].
Dmitry V RomanovA M SheyanovM D SamsonovaP G IuzbashianPublished in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2023)
The purpose of this review is to correlate current data on the molecular mechanisms of action of the drug Nimodipine with its clinical effects and applicability in mental disorders belonging to the spectrum of affective pathology. The article discusses the prospects for using the calcium channel blocker nimodipine as a method of both mono and combination therapy for bipolar disorders with various types of course. Nimodipine is a selective blocker of voltage-dependent calcium channels, a dihydropyridine derivative. By blocking L type calcium channels, it prevents the entry of calcium ions into the cell. Due to its pronounced ability to penetrate the blood-brain barrier, it has a selective effect on brain neurons and has a vasodilating, antihypertensive and normotimic effect. Nimodipine blocks LTCC channels in brain neurons, thereby influencing synaptic plasticity, transmitter release and excitation-transcription coupling, which makes it possible to influence various clinical conditions with pathology in the area of affect, including bipolar disorders with ultra-rapid cycling, and also, in cases with high resistance and intolerance to other mood stabilizers.
Keyphrases
- bipolar disorder
- subarachnoid hemorrhage
- major depressive disorder
- cerebral ischemia
- brain injury
- white matter
- spinal cord
- blood pressure
- resting state
- high resolution
- single cell
- emergency department
- angiotensin converting enzyme
- transcription factor
- big data
- cell therapy
- electronic health record
- depressive symptoms
- physical activity
- machine learning
- adverse drug
- combination therapy
- functional connectivity
- replacement therapy
- sleep quality
- loop mediated isothermal amplification
- aqueous solution