Strength of Association between Infarct Volume and Clinical Outcome Depends on the Magnitude of Infarct Size: Results from the ESCAPE-NA1 Trial.
Johanna Maria OspelMichael D HillBijoy K MenonAndrew M DemchukRyan A McTaggartRaul Gomes NogueiraAlexandre Y PoppeDiogo C HaussenWu QiuArnuv MayankMohammed A AlmekhlafiCharlotte ZernaManish JoshiMahesh V JayaramanDaniel RoyJeremy L RempelBrian H BuckMichael TymianskiMayank Goyalnull nullPublished in: AJNR. American journal of neuroradiology (2021)
The relationship between infarct volume and clinical outcome varies nonlinearly with the magnitude of infarct size. Infarct volume was linearly associated with decreased chances of achieving good outcome in patients with moderate-to-large infarcts, but not in those with small infarcts. In very large infarcts, a near-deterministic association with poor outcome was seen.