Chalcone Derivative L6H21 Reduces EtOH + LPS-Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation.

Xiaoxia KongGuicheng WuSha ChenLihua ZhangFengyuan LiTuo ShaoLi RenShao-Yu ChenHongyu ZhangCraig J McClainYunhuan Liu

Published in: Alcoholism, clinical and experimental research (2019)

Our results demonstrate that L6H21 treatment inhibits EtOH + LPS-induced liver steatosis and injury through suppression of NLRP3 inflammasome activation. L6H21 may be used as an alternative strategy for ALD prevention/treatment.

Keyphrases

nlrp inflammasome
lps induced
inflammatory response
type diabetes
combination therapy
metabolic syndrome