The Evaluation of Meropenem Dosing Regimens Against ESBL-Producing Escherichia coli in ICU Patients Using Monte Carlo Simulation.

Ei Ei WinKhaing Win HtunPramote TragulpiankitSuwida TangtrakulthamPreecha Montakantikul

Published in: Infection and drug resistance (2022)

For high MIC (>1μg/mL) patients who do not use vasopressors and have a CLcr >80 mL/min, a combination of dosage fractionation and the extended infusion was considered as an effective technique to maximize target attainment. Neither prolonged infusion nor dosage fractionation should be explored in patients using vasopressors.

Keyphrases

escherichia coli
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
low dose
prognostic factors
peritoneal dialysis
multidrug resistant
mechanical ventilation
gram negative