Salicylanilides and Their Anticancer Properties.
Tereza KauerovaMaría-Jesús Pérez-PérezPeter KollarPublished in: International journal of molecular sciences (2023)
Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Halogenated salicylanilides, which have been used for decades in human and veterinary medicine as anthelmintics, have recently emerged as candidates for drug repurposing in oncology. The most prominent example of salicylanilide anthelmintic, that is intensively studied for its potential anticancer properties, is niclosamide. Nevertheless, recent studies have discovered extensive anticancer potential in a number of other salicylanilides. This potential of their anticancer action is mediated most likely by diverse mechanisms of action such as uncoupling of oxidative phosphorylation, inhibition of protein tyrosine kinase epidermal growth factor receptor, modulation of different signaling pathways as Wnt/β-catenin, mTORC1, STAT3, NF-κB and Notch signaling pathways or induction of B-Raf V600E inhibition. Here we provide a comprehensive overview of the current knowledge about the proposed mechanisms of action of anticancer activity of salicylanilides based on preclinical in vitro and in vivo studies, or structural requirements for such an activity.
Keyphrases
- epidermal growth factor receptor
- tyrosine kinase
- signaling pathway
- cell proliferation
- advanced non small cell lung cancer
- pi k akt
- epithelial mesenchymal transition
- healthcare
- endothelial cells
- stem cells
- palliative care
- case control
- nitric oxide
- human health
- emergency department
- lps induced
- small molecule
- protein kinase
- protein protein
- amino acid
- climate change
- toll like receptor
- endoplasmic reticulum stress
- binding protein