Ibuprofen Protection Against Restrained Chronic Stress-induced Depression in Male Rats.

Masoumeh Nozari Arezo Nahavandi Motahareh Zeinivand Maryam Eslami GharaatiMina GodarziMohammad AhmadiNida Jamali-Raeufy

Published in: Basic and clinical neuroscience (2020)

The administration of ibuprofen prevents the cognitive and behavioral consequences of chronic stress. During the recovery, the plasma levels of IL-6 were not elevated by stress, and the IL-6 levels did not predict the behavioral performance of the stressed animals. The exact mechanisms of the protective effects of ibuprofen against chronic stress need to be further investigated.

Keyphrases

stress induced
depressive symptoms
postoperative pain
drug induced
heat stress
high resolution