Aetiology and outcomes of prolonged neonatal jaundice in tertiary centres: data from the China Neonatal Genome Project.

Tiantian XiaoJin WangHuijun WangHongfang MeiXinran DongYulan LuGuoqiang ChengLaishuan WangLi-Yuan HuWei LuQi NiGang LiPing ZhangYanyan QianXu LiXiaomin PengYao WangChun ShenGong ChenYa-Lan DouYun CaoLiping ChenWenqing KangLong LiXinnian PanQiufen WeiDeyi ZhuangDong-Mei ChenZhaoqing YinJianshe WangLin YangBingbing WuWen-Hao Zhou

Published in: Archives of disease in childhood. Fetal and neonatal edition (2022)

Known aetiologies were identified in approximately 80% of neonates in our cohort, and their overall outcomes were favourable. Genetic aetiology should be considered a priority in neonates with PCHB or the persistence of jaundice after 4 weeks of age. Moreover, genetic data can modify the clinical diagnosis and guide disease management, potentially improving outcomes.

Keyphrases

genome wide
electronic health record
low birth weight
gene expression
quality improvement
dna methylation
preterm infants
data analysis