Serum β-lactam concentrations in critically ill patients with cirrhosis: a matched case-control study.

Olivier LheureuxEric TrepoMaya HitesFrederic CottonFleur WolffRudy SurinJacques CreteurJean-Louis VincentThierry GustotFrederique JacobsFabio S Taccone

Published in: Liver international : official journal of the International Association for the Study of the Liver (2015)

Standard β-lactam antibiotics regimens resulted in excessive serum concentrations in two thirds of the patients with cirrhosis. This was particularly true for piperacillin/tazobactam, probably because of reduced drug clearance.

Keyphrases

gram negative
multidrug resistant
weight gain
emergency department
adverse drug