Alprazolam Reduces Freezing of Gait (FOG) and Improves FOG-Related Gait Deficiencies.

Abdullah Al JajaTéa SueMargaret T M PrengerKen N SeergobinJessica A GrahnPenny A MacDonald

Published in: Parkinson's disease (2024)

. Our results suggest that (1) anxiety induces FOG, and (2) alprazolam concomitantly reduces anxiety and FOG. Alprazolam further improved gait stability (i.e., swing time and gait variability). These findings reveal that anxiety triggers FOG in PD. Treating anxiety can reduce FOG and improve gait stability, potentially offering new therapeutic avenues for this intractable and disabling symptom in PD.

Keyphrases

cerebral palsy
sleep quality
gene expression
dna methylation
genome wide
patient reported