Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma.
David G SuDavid A SchoenfeldWael IbrahimRaysa CabrejoDijana DjureinovicRaymond BaumannDavid L RimmSajid A KhanRuth HalabanHarriet M KlugerKelly OlinoAnjela GalanJames ClunePublished in: Journal for immunotherapy of cancer (2024)
Our proteomic analysis reveals an intra-tumoral population of SMA+CAFs enriched in pure DM. Additionally, increased expressions of immune checkpoints (LAG-3 and PD-1) in LA and within tumor were associated with poorer prognosis. These findings might have therapeutic implications and help guide treatment selection in addition to informing potential prognostic significance.