A validation study of the UGT1A4 rs2011404 variant and the risk of anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population.

Jia ZhuWenpei LiuMeiling ZhangLihuan LuHongqiu PanXiaomin HeNannan WangMiaomiao YangHonggang YiShao-Wen Tang

Published in: Journal of clinical pharmacy and therapeutics (2021)

Based on a 1:4 individual matched case-control study, possessing the CC genotype at rs2011404 of the UGT1A4 gene reduces the risk of moderate or severe liver injury in Eastern Chinese Han patients receiving anti-TB treatment. Further research is warranted to explain the role of the UGT1A4 gene and its contribution to individual differences in susceptibility to ATDH.

Keyphrases

drug induced
liver injury
mycobacterium tuberculosis
south africa
adverse drug
copy number
genome wide
genome wide identification
high intensity
gene expression
dna methylation
hiv aids
pulmonary tuberculosis
hepatitis c virus
transcription factor
human immunodeficiency virus
genome wide analysis
smoking cessation