Plasma Metabolome Predicts Aortic Stiffness and Future Risk of Coronary Artery Disease and Mortality After 23 Years of Follow-Up in the General Population.
Filip OttossonGunnar EngströmMarju Orho-MelanderOlle MelanderPeter M NilsssonMadeleine JohanssonPublished in: Journal of the American Heart Association (2024)
Aortic stiffness is associated particularly with altered metabolism of acylcarnitines, cystine, and dimethylguanidino valeric acid. These metabolic disturbances predict increased risk of new-onset coronary artery disease, cardiovascular mortality, and all-cause mortality after more than 23 years of follow-up in the general population.
Keyphrases
- coronary artery disease
- cardiovascular events
- aortic valve
- percutaneous coronary intervention
- left ventricular
- pulmonary artery
- coronary artery bypass grafting
- aortic dissection
- current status
- aortic stenosis
- cardiovascular disease
- heart failure
- type diabetes
- coronary artery
- transcatheter aortic valve replacement
- pulmonary hypertension
- atrial fibrillation