Cumulative Genetic Risk and APOE ε4 Are Independently Associated With Dementia Status in a Multiethnic, Population-Based Cohort.
Katharine K BriegerHarita S VadariJessica D FaulSteven G HeeringaSharon L R KardiaKenneth M LangaJennifer A SmithJennifer J ManlyColter M MitchellKelly S BenkeErin B WarePublished in: Neurology. Genetics (2021)
Cumulative genetic risk of AD and APOE ε4 are both independent predictors of dementia in European ancestry. This study provides important insight into the polygenic nature of dementia and demonstrates the utility of polygenic scores in dementia research.