Comparison of Sepsis-1, 2 and 3 for Predicting Mortality in Septic Patients of a Middle-Income Country: A Retrospective Observational Cohort Study.
Carem Luana Machado LessaGisele BranchiniIsabela Moreira DelfinoMatheus Henrique Ramos VoosGiselle Calovi PratiniJorge Amilton HoherFernanda Bordignon NunesPublished in: Journal of intensive care medicine (2023)
The study found that most patients met the diagnostic criteria for sepsis using the three methods. Sepsis-2 showed greater sensitivity to predict mortality, while Sequential Organ Failure Assessment showed low accuracy, but was the only significant one. Furthermore, quick Sequential Organ Failure Assessment (qSOFA) had the highest specificity for mortality. Overall, these findings suggest that, although all three methods contribute to the diagnosis and prognosis of sepsis, Sepsis-2 is particularly sensitive in predicting mortality. Sepsis-3 shows some accuracy but requires improvement, and qSOFA exhibits the highest specificity. More research is needed to improve predictive capabilities and patient outcomes.
Keyphrases
- acute kidney injury
- septic shock
- intensive care unit
- end stage renal disease
- cardiovascular events
- chronic kidney disease
- newly diagnosed
- risk factors
- prognostic factors
- peritoneal dialysis
- type diabetes
- mental health
- physical activity
- cardiovascular disease
- patient reported outcomes
- tyrosine kinase
- clinical evaluation