MRI and fluid biomarkers reveal determinants of myelin and axonal loss with aging.

Keenan A WalkerMichael R DugganZhaoyuan GongHeather E DarkJohn P LaporteMary E FaulknerYang AnAlexandria LewisAbhay R MoghekarSusan M ResnickMustapha Bouhrara

Published in: Annals of clinical and translational neurology (2023)

Plasma biomarkers of neuronal injury and astrogliosis are associated with reduced axonal density and region-specific myelin content. Axonal loss and demyelination may co-occur with neurodegeneration and astrogliosis ahead of clinically meaningful cognitive decline.

Keyphrases

cognitive decline
spinal cord injury
mild cognitive impairment
optic nerve
white matter
magnetic resonance imaging
contrast enhanced
genome wide
single cell
multiple sclerosis
dna methylation
subarachnoid hemorrhage
magnetic resonance
brain injury